Nata a Perugia il 31/5/1956
1982 Laurea in Medicina e Chirurgia conseguita nell'Universita' di Perugia, (110/110 e lode). 1987 Specializzazione in Medicina Interna (50/50 e lode).
Nel 1987 e nel 1989 attività di ricerca presso l'Atherosclerosis Research Group dell'Universita' di Vienna (Austria).
Dal 2001: Professore Associato di Medicina Interna afferente al Dipartimento di Medicina Clinica e Sperimentale della  Facolta' di Medicina e Chirurgia dell' Universita' degli Studi di Perugia.
Attività didattica è titolare dell’insegnamento di “Medicina Interna” per il Corso di Laurea in Odontoiatria e Protesi Dentaria dell‘Università degli Studi di Perugia.
E’ titolare inoltre di insegnamenti nell’ambito delle Scuole di Specializzazione in “Medicina Interna” e di “Cardiologia” dell’Università degli Studi di Perugia. Fa parte del Collegio Docenti del Dottorato di Ricerca in “Patologia e Clinica dell’Arteriosclerosi”  dell’ Università degli Studi di Perugia.
Attività scientifica: l'attivita' scientifica e' documentata da numerose  pubblicazioni su riviste nazionali ed internazionali, abstracts, e capitoli di libri. E’ stata invitata in qualità di Relatrice  o ha presentato contributi scientifici in forma di comunicazioni orali o poster  a numerosi Congressi Scientifici Nazionali ed Internazionali
Attività clinica: svolge attivita' assistenziale nei Reparti di degenza della Sezione di Medicina Interna, Angiologia e Malattie da Arteriosclerosi del Policlinico di Perugia con equiparazione a Dirigente Medico di I° livello.
E ’ responsabile dell’Ambulatorio di Lipidologia clinica della suddetta Sezione.
 

Pubblicazioni recenti (2000-2009)

1.       Lupattelli G, Lombardini R, Schillaci G, Ciuffetti G, Marchesi S, Siepi D, Mannarino E. Flow-mediated vasoactivity and circulating adhesion molecules in hypertriglyceridemia: association with small, dense LDL cholesterol particles. Am Heart J. 2000;140(3):521-6.

2.       Marchesi S, Lupattelli G, Siepi D, Schillaci G, Vaudo G, Roscini AR, Sinzinger H, Mannarino E.  Short-term atorvastatin treatment improves endothelial function in hypercholesterolemic women. J Cardiovasc Pharmacol. 2000;36(5):617-21

3.       Pirro M, Lupattelli G, Siepi D, Palumbo B, Roscini AR, Marchesi S, Schillaci G, Mannarino E. Postprandial lipemia and associated metabolic disturbances in healthy and hyperlipemic   postmenopausal women. Metabolism. 2001 Mar;50(3):330-4.

4.       Schillaci G, Vaudo G, Reboldi G, Verdecchia P, Lupattelli G, Pasqualini L, Porcellati C, Mannarino E.  High-density lipoprotein cholesterol and left ventricular hypertrophy in essential hypertension. J Hypertens. 2001;19(12):2265-70.

5.       Sinzinger H, Lupattelli G, Chehne F, Oguogho A, Furberg CD.  Isoprostane 8-epi-PGF2alpha is frequently increased in patients with muscle pain and/or CK-elevation after HMG-Co-enzyme-A-reductase inhibitor therapy. J Clin Pharm Ther. 2001 Aug;26(4):303-10.

6.       Chehne F, Oguogho A, Lupattelli G, Budinsky AC, Palumbo B, Sinzinger H. Increase of isoprostane 8-epi-PGF(2alpha)after restarting smoking. Prostaglandins Leukot Essent Fatty Acids. 2001 Jun;64(6):307-10.

7.       Ciuffetti G, Lombardini R, Pirro M, Lupattelli G, Mannarino E.  Clopidogrel: hemorheological effects in subjects with subclinical atherosclerosis. Clin Hemorheol Microcirc. 2001;25(1):31-9.

8.       Schillaci G, Vaudo G, Marchesi S, Lupattelli G, Reboldi G, Verdecchia P, Pasqualini L, Mannarino E. Optimizing assessment of carotid and femoral intima-media thickness in essential hypertension. Am J Hypertens. 2001 Oct;14(10):1025-31.

9.       Marchesi S, Lupattelli G, Siepi D, Roscini AR, Vaudo G, Sinzinger H, Mannarino E. Oral L-arginine administration attenuates postprandial endothelial dysfunction in young healthy males. J Clin Pharm Ther. 2001 Oct;26(5):343-9.

10.   Lupattelli G, Marchesi S, Roscini AR, Siepi D, Gemelli F, Pirro M, Sinzinger H, Schillaci G, Mannarino E. Direct association between high-density lipoprotein cholesterol and endothelial function in hyperlipemia. Am J Cardiol. 2002;90(6):648-50.

11.   Chehne F, Oguogho A, Lupattelli G, Palumbo B, Sinzinger H. Effect of giving up cigarette smoking and restarting in patients with clinically manifested atherosclerosis. Prostaglandins Leukot Essent Fatty Acids. 2002 Nov;67(5):333-9.

12.   Schillaci G, Pasqualini L, Vaudo G, Lupattelli G, Pirro M, Marchesi S, Porcellati C, Mannarino E.  Prognostic value of treatment-induced changes in twenty-four-hour mean and pulse pressures in adult hypertensive patients. Am J Cardiol. 2002 Oct 15;90(8):896-9.

13.   Sinzinger H, Chehne F, Lupattelli G.  Oxidation injury in patients receiving HMG-CoA reductase inhibitors: occurrence in patients without enzyme elevation or myopathy. Drug Saf. 2002;25(12):877-83.

14.   Lupattelli G, Pasqualini L, Siepi D, Marchesi S, Pirro M, Vaudo G, Ciuffetti G, Mannarino E. Increased postprandial lipemia in patients with normolipemic peripheral arterial disease. Am Heart J. 2002 ,143(4):733-8.

15.   Siepi D, Marchesi S, Lupattelli G, Paltriccia R, Vaudo G, Pirro M, Roscini AR, Scarponi AM, Sinzinger H, Mannarino E.  Postprandial endothelial impairment and reduced glutathione levels in postmenopausal women. Ann Nutr Metab. 2002;46(1):32-7.

16.   Palumbo B, Lupattelli G, Siepi D, Bianchi A, Anniboletti PF, Blandini V, Sinzinger H, Mannarino E, Palumbo R. Correlation of lipoprotein(a) levels and myocardial stress thallium scintigraphy pattern in different entities of CHD severity. Wien Klin Wochenschr. 2002 Dec 30;114(23-24):987-91.

17.   Marchesi S, Lupattelli G, Lombardini R, Roscini AR, Siepi D, Vaudo G, Pirro M, Sinzinger H, Schillaci G, Mannarino E. Effects of fenofibrate on endothelial function and cell adhesion molecules during post-prandial lipemia in hypertriglyceridemia. J Clin Pharm Ther. 2003 Oct;28(5):419-24.

18.   Lupattelli G, Marchesi S, Lombardini R, Siepi D, Bagaglia F, Pirro M, Ciuffetti G, Schillaci G, Mannarino E.  Mechanisms of high-density lipoprotein cholesterol effects on the endothelial function in hyperlipemia. Metabolism. 2003 Sep;52(9):1191-5.

19.   Marchesi S, Vaudo G, Lupattelli G, Mannarino E. Assessment of brachial artery flow-mediated vasodilatation: comment on the article by Van Doornum et al. Arthritis Rheum. 2003 Sep;48(9):2700; author reply 2700.

20.   Schillaci G, Pasqualini L, Vaudo G, Lupattelli G, Pirro M, Gemelli F, De Sio M, Porcellati C, Mannarino E.  Effect of body weight changes on 24-hour blood pressure and left ventricular mass in hypertension: a 4-year follow-up. Am J Hypertens. 2003 Aug;16(8):634-9.

21.   Pirro M, Siepi D, Lupattelli G, Roscini AR, Schillaci G, Gemelli F, Vaudo G, Marchesi S, Pasqualini L, Mannarino E. Plasma C-reactive protein in subjects with hypo/ hyperalphalipoproteinemias. Metabolism. 2003 Apr;52(4):432-6.

22.   Vaudo G, Marchesi S, Lupattelli G, Pirro M, Pasqualini L, Roscini AR, Siepi D, Schillaci G, Mannarino E. Early vascular damage in primary hypoalphalipoproteinemia. Metabolism. 2003 Mar;52(3):328-32.

23.   Marchesi S, Pasqualini L, Lombardini R, Vaudo G, Lupattelli G, Pirro M, Schillaci G,  Mannarino E. Prostaglandin E1 improves endothelial function in critical limb ischemia.  J Cardiovasc Pharmacol. 2003 Feb;41(2):249-53.

24.   Vaudo G, Marchesi S, Siepi D, Bagaglia F, Paltriccia R, Pirro M, Schillaci G, Lupattelli G, Mannarino E. Relevance of homocysteine on brachial flow-mediated vasodilatation and carotid and femoral intima-media thickness in patients with hypercholesterolemia. Am J Cardiol. 2004 Jun 1;93(11):1413-6.

25.   Lupattelli G, Scarponi AM, Vaudo G, Siepi D, Roscini AR, Gemelli F, Pirro M, Latini RA, Sinzinger H, Marchesi S, Mannarino E. Simvastatin increases bone mineral density in hypercholesterolemic postmenopausal women. Metabolism. 2004 Jun;53(6):744-8.

26.   Palumbo B, Siepi D, Lupattelli G, Sinzinger H,  Fiorucci G, Anniboletti PF,  Latini RA,  Mannarino E, Palumbo R. Usefulness of Brain Natriuretic Peptide levels to discriminate patients with stable angina pectoris without and with electrocardiographic myocardial ischemia and patients with healed myocardial infarction. Am J Cardiol 2004, 94, 780-783.

27.   Mannarino E, Lupattelli G, Schillaci G. A 32-year-old woman with breast swelling and crepitant rales. CMAJ. 2004 Nov 9;171(10):1172.

28.   Lupattelli G, Marchesi S, Lombardini R, Roscini AR, Trinca F, Gemelli F, Vaudo G, Mannarino E. Artichoke juice improves endothelial function in hyperlipemia. Life Sci. 2004 Dec 31;76(7):775-82.

29.    Marchesi S, Lupattelli G, Lombardini R, Sensini A, Siepi D, Mannarino M, Vaudo G, Mannarino E. Acute inflammatory state during influenza infection and endothelial function. Atherosclerosis. 2005 Feb;178(2):345-50.

30.   Calabresi L, Pisciotta L, Costantin A, Frigerio I, Eberini I, Alessandrini P, Arca M, Bittolo Bon G, Boscutti G, Busnach G, Frasca G, Gesualdo L, Gigante M, Lupattelli G, Montali A, Pizzolitto S, Rabbone I, Rolleri M, Ruotolo G, Sampietro T, Sessa A, Vaudo G, Cantafora A, Veglia F, Calandra S, Bertolini S, Franceschini G.  The Molecular Basis of Lecithin:Cholesterol Acyltransferase Deficiency Syndromes. A Comprehensive Study of Molecular and Biochemical Findings in 13 Unrelated Italian Families. Arterioscler Thromb Vasc Biol. 2005 Jun 30.

31.   Pisciotta L, Calabresi L, Lupattelli G, Siepi D, Mannarino MR, Moleri E, Bellocchio A, Cantafora A, Tarugi P, Calandra S, Bertolini S. Combined monogenic hypercholesterolemia and hypoalphalipoproteinemia caused by mutations in LDL-R and LCAT genes. Atherosclerosis. 2005 Sep;182(1):153- 9. 

32.     Ronti T, Lupattelli G, Mannarino E.  The endocrine function of adipose tissue: an update. Clin Endocrinol (Oxf). 2006 Apr;64(4):355-65. Review.

33.   Lupattelli G, Marchesi S, Siepi D, Bagaglia F, Palumbo B, Roscini AR, Schillaci G, Vaudo G, Sinzinger H, Mannarino E. Natriuretic peptides levels are related to HDL-cholesterol with no influence on endothelium dependent vasodilatation. Vasa. 2006 Nov;35(4):215-20.

34.   Vaudo G, Marchesi S, Siepi D, Brozzetti M, Mannarino MR, Pirro M, Schillaci G, Ciuffetti G, Lupattelli G, Mannarino E. Metabolic syndrome and preclinical atherosclerosis: focus on femoral arteries.  Metabolism. 2007 Apr;56(4):541-6.

35.    Marchesi S, Lupattelli G, Sensini A, Lombardini R, Brozzetti M, Roscini AR, Siepi D, Mannarino E, Vaudo G. Racial difference in endothelial function: role of the infective burden.  Atherosclerosis. 2007 Mar;191(1):227-34.

36.   Marchesi S, Vaudo G, Lupattelli G, Lombardini R, Roscini AR, Brozzetti M, Siepi D, Mannarino E.Fat distribution and endothelial function in normal-overweight menopausal women.J Clin Pharm Ther. 2007 Oct;32(5):477-82.

37.   Vaudo G, Marchesi S, Siepi D, Brozzetti M, Lombardini R, Pirro M, Alaeddin A, Roscini AR, Lupattelli G, Mannarino E. Human endothelial impairment in sepsis.Atherosclerosis. 2008 Apr;197(2):747-52.

38.   Lupattelli G, Marchesi S, Ronti T, Lombardini R, Bruscoli S, Bianchini R, Vaudo G, Riccardi C, Mannarino E.Endothelial dysfunction in vivo is related to monocyte resistin mRNA expression.J Clin Pharm Ther. 2007 Aug;32(4):373-9.

39.   Poli A, Marangoni F, Paoletti R, Mannarino E, Lupattelli G, Notarbartolo A, Aureli P, Bernini F, Cicero A, Gaddi A, Catapano A, Cricelli C, Gattone M, Marrocco W, Porrini M, Stella R, Vanotti A, Volpe M, Volpe R, Cannella C, Pinto A, Del Toma E, La Vecchia C, Tavani A, Manzato E, Riccardi G, Sirtori C, Zambon A; Nutrition Foundation of Italy. Non-pharmacological control of plasma cholesterol levels.Nutr Metab Cardiovasc Dis. 2008 Feb;18(2):S1-16.

40.   Siepi D, Marchesi S, Vaudo G, Lupattelli G, Bagaglia F, Pirro M, Brozzetti M, Roscini AR, Mannarino E. Preclinical vascular damage in white postmenopausal women: the relevance of osteoprotegerin.Metabolism. 2008 Mar;57(3):321-5.

41.    Lombardini R, Marchesi S, Collebrusco L, Vaudo G, Pasqualini L, Ciuffetti G, Brozzetti M, Lupattelli G, Mannarino E. The use of osteopathic manipulative treatment as adjuvant therapy in patients with peripheral arterial disease. Man Ther. 2009 Aug;14(4):439-43

42.   Mannarino E, Pirro M, Cortese C, Lupattelli G, Siepi D, Mezzetti A, Bertolini S, Parillo M, Fellin R, Pujia A, Averna M, Nicolle C, Notarbartolo A. Effects of a phytosterol-enriched dairy product on lipids, sterols and 8-isoprostane in hypercholesterolemic patients: a multicenter Italian study. Nutr Metab Cardiovasc Dis. 2009 Feb;19(2):84-90.